◀ Prev · Parts · Full · Next ▶

The classical complement pathway can also be activated by apoptotic cells, necrotic cells, and acute phase proteins.cite-ref-overview-of-complement-1-1[1]cite-ref-complement-history-3-1[3]cite-ref-c1q-4-0[4]

• Complement cascade

• Initiation

• Formation of C4b convertase

• Regulation of C4b

• Formation of C3-convertase.

• C3b function and structure.

• Formation of C5 convertase and MAC

• Clinical significance

• See also

• References

The classical pathway is distinct from the other complement pathways in its unique activation triggers and cascade sequence. Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade of reactions eventually leading to the membrane attack complex.

◀ Prev · Parts · Full · Next ▶